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Designed specifically for pharmaceutical oral liquid production (syrups, suspensions, solutions)
This system adheres to GMP guidelines to ensure consistent formulation homogeneity, stable organoleptic properties, and strict microbial control.
Description
Core Functions
Functional modules | Functional Description |
Efficient dissolution and dispersion | - Heating and stirring (40~80 ℃ ) accelerates the dissolution of poorly soluble drugs. |
Taste and appearance control | - Accurately add flavoring agents and pigments to improve palatability (especially for children). |
Microbiological Control | - Pasteurization (60-85 °C ) or adding preservatives (such as sodium benzoate) to ensure that the microbial limits are met. |
High viscosity liquid handling | - Frame agitator + anchor scraper design to prevent syrup-like liquids from crystallizing on the wall. |
Data traceability | - Record the preparation parameters (temperature, stirring speed, additive dosage) to meet GMP audit requirements. |
Design Principle
1. Uniformity and stability design
· Hybrid Dynamics Optimization :
o For high viscosity liquids (such as syrup), use low speed high torque stirring (10-50rpm) to avoid vortex cavities.
o When preparing the suspension, the homogenizer is cycled (3-5 times) to ensure uniform dispersion of the particles (D90 ≤ 50 μm).
· Temperature stratification control :
o Interlayer heat transfer oil or hot water circulation, temperature control accuracy ±1 ℃ (to prevent sugar caramelization or component degradation).
2. Anti-pollution and clean design
· Open and closed compatible :
o The liquid preparation tank can be equipped with a closed cover (dust-proof) or an open feeding port (suitable for adding solid raw materials).
o The key contact parts are designed without dead angles (rounded transition, quick-release interface), which is convenient for CIP cleaning.
· Material selection :
o The inner wall of stainless steel is electrolytically polished (Ra≤0.6μm) to reduce sugar or drug residues.
o Silicone/PTFE seals (high temperature resistant, no extractables).
3. Sensory quality control
· Degassing and defoaming :
o The vacuum degassing tank (-0.05~-0.08MPa) removes bubbles from the liquid medicine and improves its transparency.
o Automatic addition of defoamers (such as polydimethylsiloxane) to avoid foam overflow during filling.
· Online seasoning :
o A multi-channel metering pump (accuracy ±0.5%) adds flavors and sweeteners in proportion to avoid taste differences between batches.
4. Automation and flexibility
· Recipe Management :
o Store multiple product recipes (such as syrups of different flavors and concentrations) and switch production with one click.
o Automatic calculation of solvent volume (based on feedstock density and concentration).
· Modular expansion :
o Supports capacity expansion from R&D level (50L) to mass production level (2000L).
o Filling lines can be integrated (such as automatic filling and sealing of oral liquid bottles).
Application
· Chinese medicine oral solution : mixing and concentration of extract and auxiliary materials (honey, preservatives).
· Children's medication : flavoring and filling of fruit-flavored antipyretic syrup.
· Health products : preparation and degassing of vitamin oral solution.
· OTC drugs : homogenization and stability control of gastrointestinal regulation suspensions.
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